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2 edition of Carboplatin ototoxicity found in the catalog.

Carboplatin ototoxicity

Mark Wake

Carboplatin ototoxicity

by Mark Wake

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  • 18 Currently reading

Published by University of Birmingham in Birmingham .
Written in English


Edition Notes

Thesis (M.D.) - University of Birmingham, Department of Surgery, 1996.

Statementby Mark Wake.
ID Numbers
Open LibraryOL16750404M

Measles, mumps and rubella vaccine, live is predicted to increase the risk of generalised infection (possibly life-threatening) when given with carboplatin. Public Health England advises avoid (refer to Green Book). CARBOPLATIN & CISPLATIN OTOTOXICITY. Cisplatin is an ototoxic drug best known for damaging outer hair cells (OHC) and inner hair cells (IHC); however, platinum-based drugs can also affect vulnerable areas of the central nervous system. Carboplatin is considered less ototoxic than cisplatin.

Monitor for peripheral neuropathy (e.g., paresthesias), ototoxicity, and visual disturbances. Monitor serum electrolyte studies, because carboplatin has been associated with decreases in sodium, potassium, calcium, and magnesium. Special precautions may be warranted for patients on diuretic therapy. Patient & Family Education. Carboplatin is an anticancer drug ("antineoplastic" or "cytotoxic") chemotherapy drug. Carboplatin is classified as an "alkylating agent." Carboplatin is used to treat ovarian cancer. Carboplatin is also used for other types of cancer, including lung, head and neck, endometrial, esophageal, bladder, breast, and cervical; central nervous.

Drug-Drug:qrisk of nephrotoxicity and ototoxicity with other nephrotoxic and ototoxic drugs (aminoglycosides, loop diuretics).qrisk of hypokalemia and hypomagnesemia withloopdiureticsand amphotericinB. marrow depression with other antineoplasticsor radiationtherapy. Maypantibodyresponsetolive File Size: KB. (including carboplatin and doxorubicin hydrochloride) or radia-tion. No studies to date have attempted to analyze the specific ef-fects of cisplatin on the risk of secondary solid tumors. The studies on solid tumors were also limited by relatively short follow-up times. Cisplatin-based treatment without radiation was associated with aFile Size: KB.


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Carboplatin ototoxicity by Mark Wake Download PDF EPUB FB2

Carboplatin is the principal agent in all retinoblastoma chemotherapy protocols reported to date. Platinum-induced ototoxicity manifests as bilateral high-frequency sensorineural hearing loss, 6,7 the incidence and severity of which increase with the cumulative dose.

Carboplatin, although considerably less ototoxic than cisplatin, has been Cited by: Implement fall prevention strategies, especially if patient exhibits balance deficits related to ototoxicity (See Appendix E). Patient/Client-Related Instruction Advise patient to guard against infection (frequent hand washing, etc.), and to avoid crowds and contact with persons with contagious diseases.

Thirteen children received carboplatin at a median dose of mg/m 2. In this subgroup, 6 (%) patients suffered from hearing impairments. In 4 patients, the hearing impairments had an impact on the main speech frequencies. Our results demonstrate an ototoxic effect of carboplatin similar to that of by: A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text.

Ototoxicity is a compendium of information on the ototoxic potential of clinically useful drugs. Each section of this thorough text is written by a leading authority in the field.

The book reviews the important classes of medications known to cause ototoxicity and their mechanisms. Clinical manifestations, what is known about pathophysiology, strategies for prevention and treatment, and.

Ototoxicity is found among people who take Carboplatin, especially for people who are male, old, have been taking the drug for. Platinum complexes like cisplatin and carboplatin (Fig. ) exert their antitumour effects by forming DNA adducts and subsequent inhibition of DNA replication and have an important role in the treatment of several solid tumours.

Besides myelosuppression, nephrotoxicity and ototoxicity are dose-limiting for cisplatin, whereas thrombocytopenia is dose-limiting for carboplatin. Patients with medulloblastoma are exposed to ototoxic treatments including radiation therapy and platinum chemotherapy. The favorable toxicity profile of carboplatin led us to substitute this chemotherapeutic agent for cisplatin in the HIT, HIT-MED, and HIT chemotherapy protocols.

We retrospectively investigated its consequences in terms of overall survival and ototoxicity Cited by: Carboplatin is also ototoxic, especially when delivered at myeloablative doses for autologous bone marrow transplantation, and potentiate the ototoxicity of previous cisplatin (2,4).

The SIOPEN HR-NBL-1 trial has randomized patients for megatherapy to receive busulfan-melphalan (BUMEL) or carboplatin-etoposide-melphalan (CEM). A summary of the recent literature reporting the prevalence of ototoxicity associated with various cancer populations is presented in Table 1.

It is interesting to note that the burden of morbidity related to ototoxic agents is substantially higher in very young children 2, 3, 6, 14 and in those who receive higher cumulative doses of Cited by:   For assessment of the ototoxic potential of carboplatin [cis-diammine-1,1-cyclobutane dicarboxylate platinum(II); CBDCA], pure-tone audiograms were evaluated in 27 patients receiving a total of doses of carboplatin in the range of – mg/m2.

Pure-tone audiometry (PTA) was done immediately prior to and 4 weeks after the administration of 80 doses (67%).Cited by: Carboplatin-induced ototoxicity remains poorly defined but is of potential great consequence in children with retinoblastoma. We retrospectively assessed the incidence of ototoxicity and its risk.

Carboplatin is also known to be ototoxic.” Managing any drug-induced ear problems by learning the symptoms could avoid any longer-term chronic conditions. How Do Chemotherapy Drugs Cause Ototoxicity.

Some chemotherapy drugs like Cisplatin can cause ototoxicity if used long term. As the drug builds up in your body, your risk increases. Carboplatin is frequently used to replace cisplatin because of its similar mode of action, but with lower rates of ototoxicity, nephrotoxicity, neurotoxicity and emesis.

5 However, large randomised trials using modern chemotherapy schedules that compare its efficacy and Cited by: PARAPLATIN® (carboplatin) Injection is supplied as a sterile, pyrogen-free, 10 mg/mL aqueous solution of carboplatin.

Carboplatin is a platinum coordination compound. The chemical name for carboplatin is platinum, diammine[1,1-cyclobutanedicarboxylato(2-)-O,O′]- (SP), and carboplatin has the following structural formula. In summary, treatment with carboplatin carries a significant risk of ototoxicity in children with retinoblastoma, especially in children younger than 6 months of age.

The dosing of carboplatin should be adjusted for body weight or by using an AUC-dosing Cited by: Other platins (notably, carboplatin) are less ototoxic than cisplatin but maybe less effective; therefore, despite the high risk of ototoxicity, cisplatin remains the agent of choice for hepatoblastoma and many other childhood solid tumors for the foreseeable future.

Lokich J, Anderson N. Carboplatin versus cisplatin in solid tumors: an analysis of the literature. Ann Oncol ; Cavaletti G, Bogliun G, Zincone A, et al. Neuro- and ototoxicity of high-dose carboplatin treatment in poor prognosis ovarian cancer patients.

Anticancer Res ; Lambert MP, Shields C, Meadows AT. Carboplatin, cis-diammine(cyclobutane-1, 1-dicarboxylato)platinum(II) has been shown to be an active agent for acute myeloid leukemia. This second-generation platinum drug has less nephrotoxicity and ototoxicity but more myelotoxicity than does the first-generation platinum drug cisplatin.

The study was designed to elucidate whether their. Carboplatin injection solution is an anti-cancer medication indicated for the initial treatment of advanced ovarian carcinoma in established combination with other approved chemotherapeutic agents. One established combination regimen consists of carboplatin injection and latin injection is also indicated for the palliative treatment of patients with.

A new animal model of ototoxicity is presented using intravenous carboplatin in adult chinchillas. A range of physiological and morphological effects was produced using doses calculated from the recommended therapeutic range (– mg/m 2).Auditory thresholds to tone pips stimuli were monitored using brain stem evoked responses (ABR).Cited by:   Ototoxicity affects the inner ear, which is essential in both hearing and balance.

High-dose carboplatin can also induce auditory dysfunction with a clinical picture that is largely the same as that after cisplatin therapy.

9, Auditory function must be monitored carefully because the toxicity can become by:   Decem — Ototoxicity is a well-recognized adverse effect of cisplatin, resulting in hearing loss and tinnitus. It is often dose-limiting and can hamper optimal cisplatin-based.